"News from CLUES" Spring 2021 edition is here!


 Edición en español

More information about topics in the 2021 newsletter
  • Up-to-date information about COVID-19 vaccines  (LINK)
  • Global Rheumatology Alliance COVID-19 Registry:  (LINK)
  • More about hydroxychloroquine and COVID-19 (LINK)

Download the prior issues of the CLUES newsletter here:  (2020 edition, English) (2020 edition, español) (2018 edition)

CLUES Participants --   

We want to hear from you!  Please let us know if you have moved or changed phone numbers, or if you would like further information about the CLUES study.  Email us at [email protected]


CLUES publications

Perceived Stress and Prediction of Worse Disease Activity and Symptoms in a Multiracial, Multiethnic Systemic Lupus Erythematosus Cohort. Patterson, S., Trupin, L., Hartogensis, W., DeQuattro, K., Lanata, C., Gordon, C., Barbour, K.E., Greenlund, K.J., Dall'Era, M., Yazdany, J. and Katz, P. Arthritis Care Res (2023). view/download manuscript

The association of trauma with self-reported flares and disease activity in systemic lupus erythematosus (SLE). Katz P, Patterson SL, DeQuattro K, Lanata CM, Barbour KE, Greenlund KJ, Gordon C, Criswell LA, Dall'Era M, Yazdany J. Rheumatology (Oxford) (2022 Dec 8:keac690). view/download manuscript

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosus. Andreoletti G, Lanata CM, Paranjpi I, Jain TS, Nititham J, Taylor KE, Combes AJ, Maliskova L, Ye J, Katz P, Dall’Era M, Yazdany J, Criswell LA, Sirota M.  Commun Bio 4, 488 (2021). view/download manuscript


The impact of limited health literacy on patient-reported outcomes in systemic lupus erythematosus. Katz P, Dall’Era M, Trupin L, Rush S, Murphy LB, Lanata C, Criswell LA, Yazdany J. The impact of limited health literacy on patient-reported outcomes in systemic lupus erythematosus. Arthritis Care Res January 2021 73(1):110-119. View/download manuscript


Depression and the Patient Reported Outcomes Measurement Information System in Systemic Lupus Erythematosus. Dietz B, Katz P, Dall'Era M, Murphy L, Lanata C, Trupin L, Criswell C, Yazdany J.  Arthritis Care Res January 2021 73(1):48-54. View/download manuscript


Physical Inactivity Independently Predicts Incident Depression in a Multi-Racial/Ethnic Systemic Lupus Cohort. Patterson SL, Trupin L, Yazdany J, Dall'Era M, Lanata C, Dequattro K, Hartogensis W, Katz P. Arthritis Care Res (Hoboken). 2021 Jan 9. View/download manuscript


High Disease Severity Among Asians in a US Multiethnic Cohort of Individuals with Systemic Lupus ErythematosusDeQuattro K, Trupin L, Rush S, Criswell LA, Lanata L, Dall'Era M, Katz P, Yazdany J. Arthritis Care Res  18 December 2020. view/download manuscript


Relationships Between Adverse Childhood Experiences and Health Status in Systemic Lupus Erythematosus. DeQuattro K, Trupin L, Li J, Katz PP, Murphy LB, Yelin EH, Rush S, Lanata C, Criswell LA, Dall'Era M, Yazdany J. Arthritis Care and Research. May 2019. We found that adults with lupus who have a history of adverse childhood experiences (ACEs)—such as abuse, neglect and household challenges—report higher disease activity, depression and poorer overall health as compared to those without ACEs. View/download manuscript


Integrative Multi-Omics Analysis Identifies Three Distinct Subtypes of Systemic Lupus Erythematous. Lanata CM, Parajnpe I, Nititham J, Taylor K, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Chung SA, Rhead B, Barcellos B, Trupin L, Katz P, Dall’Era M, Yazdany J, Sirota M, Criswell LA. Nature Communications. Aug 2019.

In this paper we utilized clinical and genomic data to see if we could better define distinct groups of patients under the big umbrella of that we call lupus. We found 3 groups  that varied from mild manifestations to more severe manifestations. We also found that some genes were programmed differently between these three groups. View/download manuscript.


Psychometric evaluation of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS®) in a multi-racial, multi-ethnic systemic lupus erythematosus (SLE) cohort. Katz P, Yazdany J, Trupin L, Rush S, Helmick CG, Murphy LB, Lanata C, Criswell LA, Dall'Era M. Arthritis Care and Research. December 2019.

This paper examined the usefulness of a new set of questionnaires for people with lupus and among different racial/ethnic groups. We found that these questionnaires are relevant to people with lupus and will expand the topics that can be studied (to include sleep, “brain fog,” and social interactions) without adding long questionnaires. View/download manuscript


Quality of Care for the Screening, Diagnosis, and Management of Lupus Nephritis Across Multiple Healthcare Settings. Aggarwal I, Li J, Trupin L, Gaynon L, Katz PP, Lanata C, Criswell L, Murphy LB, Dall'Era M, Yazdany J.  Arthritis Care and Research. May 2019.

In this study, we examined the quality of clinical care for kidney disease (lupus nephritis) across 25 clinical sites. We found the quality of healthcare for those with lupus nephritis was high in the Bay Area. However, the study identified room for improvement in regularly screening for kidney disease among people with lupus. View/download manuscript


Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ. Nature Biotechnology 2017;36:89-94. 

This paper described a new technology that allows us to measure all the genes that are expressed in a single cell. It is a powerful tool that will help us further study and understand the causes of lupus. View/download manuscript 


California Lupus Surveillance Project publications (predecessor to CLUES)

Mortality among minority populations with systemic lupus erythematosus, including Asian and Hispanic status: The California Lupus Surveillance Project, 2007-2017. Gianfrancesco MA, Dall’Era M, Murphy LB, Helmick CG, Li J, Rush S, Trupin L, Yazdany J. Morbidity and Mortality Weekly Report (MMWR); 19 Feb 2021. View/download manuscript


Racial/Ethnic Differences in Prevalence of and Time to Onset of SLE Manifestations: The California Lupus Surveillance Project (CLSP). Maningding E, Dall'Era M, Trupin L, Murphy LB, Yazdany J. Arthritis Care and Research. May 2019.

This study determined that severe manifestations of systemic lupus erythematosus are more common and occur earlier in the disease course among Blacks, Asians, and Hispanics compared to Whites.  View/download manuscript


The Incidence and Prevalence of Systemic Lupus Erythematosus in San Francisco County, California: The California Lupus Surveillance Project. Dall'Era M, Cisternas MG, Snipes K, Herrinton LJ, Gordon C, Helmick CG. Arthritis and Rheumatology. 2017; 69: 1996-2005.

This population-based study, funded by the Centers for Disease Control and Prevention, confirmed that the incidence and prevalence of systemic lupus erythematosus is highest among patients of Black race, followed by Hispanics, Asians, and Whites. View/download manuscript



CLUES Faculty and Staff